High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant Staphylococcus aureus Isolates from a Hospital in Central Italy-Reference-Cited by-同舟云学术

High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant Staphylococcus aureus Isolates from a Hospital in Central Italy

Published:2018-12 Issue:12 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Morroni Gianluca¹,Brenciani Andrea²,Brescini Lucia¹,Fioriti Simona²,Simoni Serena²,Pocognoli Antonella³,Mingoia Marina²,Giovanetti Eleonora⁴,Barchiesi Francesco¹,Giacometti Andrea¹,Cirioni Oscar¹

Affiliation:

1. Infectious Diseases Clinic, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy

2. Microbiology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy

3. Microbiology Unit, Clinical Pathology Laboratory Ospedali Riuniti, Ancona, Italy

4. Microbiology Unit, Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy

Abstract

Ceftobiprole is a fifth-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). One-year surveillance at the Regional Hospital of Ancona (Italy) disclosed a 12% ceftobiprole resistance rate (12/102 isolates; MIC, ≥4 mg/liter).

Funder

Polytechnic University of Marche

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01663-18

Reference22 articles.

1. Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe

2. Ceftobiprole

3. Binding of Ceftobiprole and Comparators to the Penicillin-Binding Proteins of Escherichia coli , Pseudomonas aeruginosa , Staphylococcus aureus , and Streptococcus pneumoniae