Role of iron, capsule, and toxins in the pathogenicity of Vibrio vulnificus biotype 2 for mice

Author:

Amaro C1,Biosca E G1,Fouz B1,Toranzo A E1,Garay E1

Affiliation:

1. Departamento de Microbiología, Facultad de Biología, Universidad de Valencia, Spain.

Abstract

The virulence mechanisms of Vibrio vulnificus biotype 2 have been studied and compared with those of biotype 1 in mice as the experimental animals. Biotype 2 isolates from European eels were as virulent for mice as biotype 1 strains (50% lethal dose, about 10(5) CFU per mouse); a septicemic infection developed in less than 24 h. These strains had several properties in common with biotype 1 organisms including capsule expression, uptake of various iron sources, and production of exoproteins, whose role in mouse virulence has been demonstrated. We also discuss the implication of biotype 2 strains in human infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference28 articles.

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2. Comparative study of phenotypic and virulence properties in Vibrio vulnificus biotypes 1 and 2 obtained from a European eel farm experiencing mortalities;Amaro C.;Dis. Aquat. Org.,1992

3. Electrophoretic analysis of heterogeneous lipopolysaccharides from various strains of Vibrio vulnificus biotypes 1 and 2 using silver staining and immunoblotting;Amaro C.;Curr. Microbiol.,1992

4. Austin B. and D. A. Austin. 1987. Vibrios p. 263-287. In L. M. Laird (ed.) Bacterial fish pathogens: disease in farmed and wild fish. Ellis Horwood Limited Chichester U.K.

5. First record of Vibrio vulnificus biotype 2 from diseased European eels (Anguilla anguilla);Biosca E. G.;J. Fish Dis.,1991

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