Spatiotemporal Variations in Growth Rate and Virulence Plasmid Copy Number during Yersinia pseudotuberculosis Infection-Reference-Cited by-同舟云学术

Spatiotemporal Variations in Growth Rate and Virulence Plasmid Copy Number during Yersinia pseudotuberculosis Infection

Published:2021-03-17 Issue:4 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Schneiders Stephan¹,Hechard Tifaine¹,Edgren Tomas¹,Avican Kemal²,Fällman Maria²^ORCID,Fahlgren Anna²,Wang Helen¹^ORCID

Affiliation:

1. Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

2. Department of Molecular Biology, Umeå University, Umeå, Sweden

Abstract

Pathogenic Yersinia spp. depend on the activity of a potent virulence plasmid-encoded ysc / yop type 3 secretion system (T3SS) to colonize hosts and cause disease. It was recently shown that Yersinia pseudotuberculosis upregulates the virulence plasmid copy number (PCN) during infection and that the resulting elevated gene dose of plasmid-encoded T3SS genes is essential for virulence.

Funder

Carl Tryggers Stiftelse för Vetenskaplig Forskning

Vetenskapsrådet

Svenska Sällskapet för Medicinsk Forskning

Petrus och Augusta Hedlunds Stiftelse

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00710-20

Reference25 articles.