In Vitro Activities of Quinupristin-Dalfopristin and the Streptogramin RPR 106972 against Mycoplasma pneumoniae

Author:

Izumikawa Koichi1,Hirakata Yoichi1,Yamaguchi Toshiyuki1,Yoshida Ryoji2,Tanaka Hironori2,Takemura Hiromu3,Maesaki Shigefumi2,Tomono Kazunori2,Kaku Mitsuo3,Izumikawa Kin-Ichi4,Kamihira Shimeru1,Kohno Shigeru2

Affiliation:

1. Department of Laboratory Medicine1 and

2. Second Department of Internal Medicine,2 Nagasaki University School of Medicine, Nagasaki 852,

3. Department of Microbiology, St. Marianna University School of Medicine, Kawasaki 211,3 and

4. Izumikawa Hospital, Nagasaki 859-15,4 Japan

Abstract

ABSTRACT The in vitro activities of quinupristin-dalfopristin and streptogramin RPR 106972 were determined with 44 strains of Mycoplasma pneumoniae and compared to those of macrolides, minocycline, and quinolones. All isolates tested were highly susceptible to macrolides and to quinupristin-dalfopristin (MIC at which 90% of the isolates are inhibited [MIC 90 ], 0.0625 μg/ml), followed by RPR 106972 (MIC 90 , 0.5 μg/ml), quinolones, and minocycline.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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