Expression from the adeno-associated virus p5 and p19 promoters is negatively regulated in trans by the rep protein-Reference-Cited by-同舟云学术

Expression from the adeno-associated virus p5 and p19 promoters is negatively regulated in trans by the rep protein

Published:1989-10 Issue:10 Volume:63 Page:4450-4454
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Beaton A¹,Palumbo P¹,Berns K I¹

Affiliation:

1. Hearst Microbiology Research Center, Department of Microbiology, Cornell University Medical College, New York 10021.

Abstract

The leftward two promoters of the adeno-associated virus (AAV) 2 genome were fused to reporter genes, and the constructs were used to transfect HeLa cells. The promoters functioned constitutively but were repressed in trans by the AAV rep gene product(s). The repression was relieved by adenovirus infection. Evidence which indicated an enhancer function for the inverted terminal repeat of the AAV-2 genome was also obtained.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.63.10.4450-4454.1989

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