Multicenter Evaluation of the Simplexa VZV Direct Assay for Detection of Varicella-Zoster Virus in Cerebrospinal Fluid and Lesion-Swab Specimens

Author:

Pancholi P.1ORCID,Relich R. F.2,Chandrasekaran S.3ORCID,Dunn J. J.4,Granato P. A.5ORCID,Harrington A. T.6,Hansen G. T.7,Ledeboer N. A.8,Li Q.9,Sims M. D.1011ORCID,Uphoff T. S.12,Greene W.13,Young S.14,Dhiman N.15

Affiliation:

1. The Ohio State University Wexner Medical Center, Columbus, Ohio, USA

2. Indiana University School of Medicine, Indianapolis, Indiana, USA

3. University of California Los Angeles, Los Angeles, California, USA

4. Texas Children’s Hospital, Houston, Texas, USA

5. Laboratory Alliance of Central New York, Liverpool, New York, USA

6. Loyola University Medical Center, Maywood, Illinois, USA

7. Hennepin County Medical Center, Minneapolis, Minnesota, USA

8. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

9. South Bend Medical Foundation, South Bend, Indiana, USA

10. Beaumont Health, Royal Oak, Michigan, USA

11. Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA

12. Marshfield Labs, Marshfield, Wisconsin, USA

13. Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

14. TriCore Reference Labs, Albuquerque, New Mexico, USA

15. med fusion/Quest Diagnostics, Lewisville, Texas, USA

Abstract

Varicella-zoster virus (VZV) is the etiologic agent of varicella (chickenpox) and herpes zoster (shingles) infections commonly involving skin, mucous membranes, and less frequently the central nervous system. Traditional methods for the laboratory diagnosis of these infections are time-consuming, labor-intensive, and often insensitive.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference29 articles.

1. Lopez A, Harrington T, Marin M. 2021. Varicella. In Centers for Disease Control and Prevention (ed), Epidemiology and prevention of vaccine-preventable diseases, 14th ed. Centers for Disease Control and Prevention, Atlanta, GA. http://www.cdc.gov/vaccines/pubs/pinkbook/varicella.html#zostervirus.

2. Varicella zoster virus infection

3. 3. Centers for Disease Control and Prevention. 2016. Chicken pox (varicella). https://www.cdc.gov/chickenpox/hcp/clinical-overview.html.

4. Albrecht MA. 2021. Clinical features of varicella-zoster virus infection: Chickenpox. https://www.uptodate.com/contents/clinical-features-of-varicella-zoster-virus-infection-chickenpox?search=clinical-manifestations-of-varicella-zoster-virus-infection-herpeszoster&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1. Accessed February 25 2021.

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