Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis-Reference-Cited by-同舟云学术

Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis

Published:1998-01 Issue:1 Volume:18 Page:616-628
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Götte Klaudia¹,Girzalsky Wolfgang¹,Linkert Michael¹,Baumgart Evelyn²,Kammerer Stefan³,Kunau Wolf-Hubert¹,Erdmann Ralf¹

Affiliation:

1. Institut für Physiologische Chemie, Ruhr-Universität Bochum, 44780 Bochum,1

2. Institut für Anatomie und Zellbiologie, Universität Heidelberg, 69120 Heidelberg, 2 and

3. Children’s Hospital, Laboratory of Molecular Biology, University of Munich, 80337 Munich, 3 Germany

Abstract

ABSTRACT We report the identification and molecular characterization of Pex19p, an oleic acid-inducible, farnesylated protein of 39.7 kDa that is essential for peroxisome biogenesis in Saccharomyces cerevisiae . Cells lacking Pex19p are characterized by the absence of morphologically detectable peroxisomes and mislocalization of peroxisomal matrix proteins to the cytosol. The human HK33 gene product was identified as the putative human ortholog of Pex19p. Evidence is provided that farnesylation of Pex19p takes place at the cysteine of the C-terminal CKQQ amino acid sequence. Farnesylation of Pex19p was shown to be essential for the proper function of the protein in peroxisome biogenesis. Pex19p was shown to interact with Pex3p in vivo, and this interaction required farnesylation of Pex19p.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.18.1.616

Reference82 articles.

1. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways;Albertini M.;Cell,1997

2. Ausubel F. J. Brent R. Kingston R. E. Moore D. D. Seidman J. G. Smith J. A. Struhl K. Current protocols in molecular biology. 1989 Greene Publishing Associates and Wiley-Interscience New York N.Y

3. The Hansenula polymorpha PER9 gene encodes a peroxisomal membrane protein essential for peroxisome assembly and integrity;Baerends R. J. S.;J. Biol. Chem.,1996

4. Low molecular weight GTP-binding proteins (LMGPs) involved in vesicular transport: binary switches or biological transducers?;Balch W. E.;Trends Biochem. Sci.,1990

5. Baumgart E. Morphology of peroxisomes in light- and electron microscopy Peroxisomes: biochemistry molecular biology and genetic diseases. Bugaut M. Latruffe N. 1994 37 57 Springer-Verlag Heidelberg Germany

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