Affiliation:
1. Howard Hughes Medical Institute, Gwen Knapp Center for Lupus and Immunology Research, and Department of Medicine, The University of Chicago, Chicago, Illinois 60637, 1 and
2. IDUN Pharmaceuticals Inc., La Jolla, California 920372
Abstract
ABSTRACT
The gene encoding human IAP-like protein (h
ILP
) is one of several mammalian genes with sequence homology to the baculovirus inhibitor-of-apoptosis protein (
iap
) genes. Here we show that hILP can block apoptosis induced by a variety of extracellular stimuli, including UV light, chemotoxic drugs, and activation of the tumor necrosis factor and Fas receptors. hILP also protected against cell death induced by members of the caspase family, cysteine proteases which are thought to be the principal effectors of apoptosis. hILP and Bcl-x
L
were compared for their ability to affect several steps in the apoptotic pathway. Redistribution of cytochrome
c
from mitochondria, an early event in apoptosis, was not blocked by overexpression of hILP but was inhibited by Bcl-x
L
. In contrast, hILP, but not Bcl-x
L
, inhibited apoptosis induced by microinjection of cytochrome
c
. These data suggest that while Bcl-x
L
may control mitochondrial integrity, hILP can function downstream of mitochondrial events to inhibit apoptosis.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Cited by
190 articles.
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