Detection of Point Mutations in rpoB Gene of Rifampin-Resistant Rickettsia typhi-Reference-Cited by-同舟云学术

Detection of Point Mutations in rpoB Gene of Rifampin-Resistant Rickettsia typhi

Published:1998-07 Issue:7 Volume:42 Page:1845-1846
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Troyer Jill Michelle¹,Radulovic Suzana¹,Andersson Siv G. E.²,Azad Abdu F.¹

Affiliation:

1. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland,1 and

2. Department of Molecular Biology, Uppsala University, Biomedical Center, Uppsala, Sweden2

Abstract

ABSTRACT The rpoB gene of rifampin-resistant Rickettsia typhi (Rif mutant) and wild-type R. typhi were sequenced and compared. The Rif mutant rpoB had three nucleotide substitutions, which resulted in amino acid changes at residues 151, 201, and 271 and may be the basis for the rifampin resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.7.1845

Reference11 articles.

1. Epidemiology of murine typhus.;Azad A. F.;Annu. Rev. Entomol.,1990

2. Clinical and laboratory features of murine typhus in south Texas, 1980 through 1987.;Dumler J. S.;JAMA,1991

3. Molecular basis of rifampin resistance in Mycobacterium leprae

4. Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampin resistance.;Jin D. J.;J. Mol. Biol.,1988

5. Mutation to rifampin resistance at the beginning of the RNA polymerase beta subunit gene in Escherichia coli.;Lisitsyn N. A.;Mol. Gen. Genet.,1984

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Reassessment of the genetic basis of natural rifampin resistance in the genus Rickettsia;MicrobiologyOpen;2024-07-31

2. The enigmatic biology of rickettsiae: recent advances, open questions and outlook;Pathogens and Disease;2021-03-30

3. The neglected challenge: Vaccination against rickettsiae;PLOS Neglected Tropical Diseases;2020-10-22

4. A Prospective, Open-label, Randomized Trial of Doxycycline Versus Azithromycin for the Treatment of Uncomplicated Murine Typhus;Clinical Infectious Diseases;2018-07-18

5. Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo;Antimicrobial Agents and Chemotherapy;2018-04