Role of AKT Kinase in Measles Virus Replication-Reference-Cited by-同舟云学术

Role of AKT Kinase in Measles Virus Replication

Published:2010-02-15 Issue:4 Volume:84 Page:2180-2183
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Carsillo Mary¹,Kim Dhohyung²,Niewiesk Stefan¹³

Affiliation:

1. Department of Veterinary Biosciences

2. Graduate Program in Molecular, Cellular and Developmental Biology, the Ohio State University, Columbus, Ohio

3. Department for Molecular Virology, Immunology and Medical Genetics

Abstract

ABSTRACT Many RNA and DNA viruses activate serine-threonine kinase AKT to increase virus replication. In contrast, measles virus (MV) infection leads to downregulation of AKT. This is thought to be beneficial for the virus because it correlates with immune suppression. To determine whether this is a sacrifice for the virus, we used a recombinant virus and transfected cells expressing constitutively active AKT and evaluated its effect on virus replication. In vitro , overexpression of AKT did not influence virus replication but did affect (cell-type dependent) virus release. In vivo , the recombinant virus did not abrogate inhibition of proliferation of spleen cells from MV-infected cotton rats.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01316-09

Reference18 articles.

1. Avota, E., A. Avots, S. Niewiesk, L. P. Kane, U. Bommhardt, and V. S.-S. S. ter Meulen. 2001. Disruption of Akt kinase activation is important for immunosuppression induced by measles virus. Nat. Med.7:725-731.

2. Buchkovich, N. J., Y. Yu, C. A. Zampieri, and J. C. Alwine. 2008. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat. Rev. Microbiol.6:266-275.

3. Cooray, S. 2004. The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival. J. Gen. Virol.85:1065-1076.

4. Ehrhardt, C., and S. Ludwig. 2009. A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway. Cell Microbiol.11:863-871.

5. Ganesan, L. P., G. Wei, R. A. Pengal, L. Moldovan, N. Moldovan, M. C. Ostrowski, and S. Tridandapani. 2004. The serine/threonine kinase Akt promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. J. Biol. Chem.279:54416-54425.

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