Inhibition of Herpesvirus Deoxyribonucleic Acid and Protein Synthesis by Tilorone Hydrochloride

Author:

Katz Ehud1,Margalith Eva1,Winer Bela1

Affiliation:

1. The Chanock Centre for Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Abstract

Tilorone hydrochloride at a concentration of 10 μg/ml very efficiently inhibited herpes simplex virus growth in BSC1 cells when the virus is infected at a low multiplicity of infection. The adsorption of the virus was not affected by the drug, and the penetration of the deoxyribonucleic acid of the input virus into the cytoplasm and nuclei proceeded normally when tilorone hydrochloride was present. However, newly synthesized viral deoxyribonucleic acid was not detectable under these conditions, there was a remarkable decrease in the rate of viral polypeptide synthesis, and virus particles were not formed. The inhibition of herpesvirus growth by tilorone hydrochloride was absolutely dependent on the presence of the drug in the cultures. Pretreatment of the cells with the drug did not result in resistance to herpesvirus infection after the removal of the drug.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference23 articles.

1. Antitumor activity of tilorone hydrochloride against some rodent tumors: preliminary report;Adamson R. H.;J. Natl. Cancer Inst.,1971

2. Bis-basic substituted polycyclic aromatic compounds. A new class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol and fluorene;Andrews E. R.;J. Med. Chem.,1974

3. Amelioration of Friend virus leukemia by sequential administration of viral and nonviral interferon inducers;Barker A. D.;Proc. Soc. Exp. Biol. Med.,1971

4. Inhibition of herpes simplex virus replication by camptothecin. lsr;Becker Y.;J. Med. Sci.,1973

5. Bis DEAE fluorenone (tilorone): a specific inhibitor of DNA polymerases from RNA tumor viruses;Chandra P.;FEBS Lett.,1972

Cited by 12 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3