Syndromic Panel-Based Testing in Clinical Microbiology

Author:

Ramanan Poornima1,Bryson Alexandra L.1,Binnicker Matthew J.1,Pritt Bobbi S.12,Patel Robin12

Affiliation:

1. Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA

2. Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA

Abstract

SUMMARY The recent development of commercial panel-based molecular diagnostics for the rapid detection of pathogens in positive blood culture bottles, respiratory specimens, stool, and cerebrospinal fluid has resulted in a paradigm shift in clinical microbiology and clinical practice. This review focuses on U.S. Food and Drug Administration (FDA)-approved/cleared multiplex molecular panels with more than five targets designed to assist in the diagnosis of bloodstream, respiratory tract, gastrointestinal, or central nervous system infections. While these panel-based assays have the clear advantages of a rapid turnaround time and the detection of a large number of microorganisms and promise to improve health care, they present certain challenges, including cost and the definition of ideal test utilization strategies (i.e., optimal ordering) and test interpretation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

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