Studies of the Mechanism of Action of the Aerolysin-Like Hemolysin of Aeromonas sobria in Stimulating T84 Cells To Produce Cyclic AMP-Reference-Cited by-同舟云学术

Studies of the Mechanism of Action of the Aerolysin-Like Hemolysin of Aeromonas sobria in Stimulating T84 Cells To Produce Cyclic AMP

Published:2003-03 Issue:3 Volume:71 Page:1557-1560
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Fujii Yoshio¹,Nomura Tomohiko²,Yokoyama Ritsuko¹,Shinoda Sumio³,Okamoto Keinosuke³

Affiliation:

1. Institute of Pharmacognosy

2. Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro, Tokushima, Tokushima 770-8514

3. Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka, Okayama, Okayama 700-8530, Japan

Abstract

ABSTRACT We previously reported that the aerolysin-like hemolysin of Aeromonas sobria stimulates T84 cells to produce cyclic AMP, which then emerges in the culture medium. In order to clarify the mechanism of action of the hemolysin, we examined the involvement of adenosine nucleotide. The results show that the hemolysin stimulates T84 cells to release ATP, which is then converted to adenosine by ectonucleotidase. The adenosine generated might stimulate the P1 adenosine receptors of T84 cells to produce cyclic AMP.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.3.1557-1560.2003

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