Clostridium difficile Vaccine and Serum Immunoglobulin G Antibody Response to Toxin A-Reference-Cited by-同舟云学术

Clostridium difficile Vaccine and Serum Immunoglobulin G Antibody Response to Toxin A

Published:2003-03 Issue:3 Volume:71 Page:1608-1610
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Aboudola Samer¹,Kotloff Karen L.²,Kyne Lorraine³,Warny Michel⁴,Kelly Eoin C.¹,Sougioultzis Stavros¹,Giannasca Paul J.⁴,Monath Thomas P.⁴,Kelly Ciarán P.¹

Affiliation:

1. Gastroenterology

2. Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland

3. Gerontology Divisions, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston

4. Acambis, Inc., Cambridge, Massachusetts

Abstract

ABSTRACT There is a strong association between serum antibody responses to toxin A and protection against Clostridium difficile diarrhea. A parenteral C. difficile toxoid vaccine induced very-high-level responses to anti-toxin A immunoglobulin G (IgG) in the sera of healthy volunteers. After vaccination, the concentrations of anti-toxin A IgG in the sera of all 30 recipients exceeded the concentrations that were associated with protection in previous clinical studies. Furthermore, the median concentration of serum anti-toxin A IgG in the test group was 50-fold higher than the previous threshold. These findings support the feasibility of using a vaccine to protect high-risk individuals against C. difficile -associated diarrhea and colitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.3.1608-1610.2003

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