A Genomic Island of Vibrio cholerae Encodes a Three-Component Cytotoxin with Monomer and Protomer Forms Structurally Similar to Alpha-Pore-Forming Toxins-Reference-Cited by-同舟云学术

A Genomic Island of Vibrio cholerae Encodes a Three-Component Cytotoxin with Monomer and Protomer Forms Structurally Similar to Alpha-Pore-Forming Toxins

Published:2022-05-17 Issue:5 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Herrera Alfa¹²,Kim Youngchang³⁴,Chen Jiexi¹,Jedrzejczak Robert³⁴,Shukla Shantanu¹,Maltseva Natalia³⁴,Joachimiak Grazyna³⁴,Welk Lukas³⁴,Wiersum Grant¹,Jaroszewski Lukasz⁵⁶,Godzik Adam⁵⁶,Joachimiak Andrzej³⁴⁷,Satchell Karla J. F.¹²^ORCID

Affiliation:

1. Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

2. Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

3. Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA

4. Structural Biology Center, X-Ray Science Division, Argonne National Laboratory, Lemont, Illinois, USA

5. Department of Biomedical Sciences, University of California, Riverside School of Medicine, Riverside, California, USA

6. Center for Structural Genomics of Infectious Diseases, University of California, Riverside School of Medicine, Riverside, California, USA

7. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA

Abstract

The bacterium Vibrio cholerae causes gastrointestinal, wound, and skin infections. The motility-associated killing factor A (MakA) was recently shown to be cytotoxic against colon, prostate, and other cancer cells.

Funder

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00555-21

Reference43 articles.

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4. Cry6Aa1, a Bacillus thuringiensis nematocidal and insecticidal toxin, forms pores in planar lipid bilayers at extremely low concentrations and without the need of proteolytic processing

5. The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins

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