Cyclohexane triones, novel membrane-active antibacterial agents

Author:

Lloyd W J1,Broadhurst A V1,Hall M J1,Andrews K J1,Barber W E1,Wong-Kai-In P1

Affiliation:

1. Roche Products Limited, Welwyn Garden City, Hertfordshire, United Kingdom.

Abstract

The cyclohexane triones are a novel group of synthetic antibacterial agents that are active against gram-positive bacteria, Haemophilus influenzae, and Mycobacterium smegmatis. In general, these compounds behaved in a manner similar to that of hexachlorophene, inhibiting the transport of low-molecular-weight hydrophilic substances into bacteria. Unlike cationic detergents, such as chlorhexidine, they did not cause disruption of the bacterial cytoplasmic membrane over a short time period. The most potent antibacterial cyclohexane trione studied had a reduced ability to inhibit solute transport in comparison with certain less active analogs. Cyclohexane triones may express more than a single type of antibacterial effect.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference17 articles.

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