Affiliation:
1. Department of Viroscience, Erasmus MC Rotterdam, Rotterdam, the Netherlands
2. Department of Neuroscience, Erasmus MC Rotterdam, Rotterdam, the Netherlands
Abstract
Central nervous system (CNS) disease is one of the most common extrarespiratory tract complications of influenza A virus infections, and the frequency and severity differ between seasonal, pandemic, and zoonotic influenza viruses. However, little is known about the interaction of these viruses with cells of the CNS. Differences among seasonal, pandemic, and zoonotic influenza viruses in replication efficacy in CNS cells,
in vitro
, suggest that the presence of an alternative HA cleavage mechanism and ability to attach are important viral factors. Identifying these viral factors and detailed knowledge of the interaction between influenza virus and CNS cells are important to prevent and treat this potentially lethal CNS disease.
Funder
ESCMID
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Erasmus MC | Erasmus MC Vriendenfonds
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
19 articles.
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