Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin ( hlyA ) Mutant in Gnotobiotic Piglets-Reference-Cited by-同舟云学术

Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin ( hlyA ) Mutant in Gnotobiotic Piglets

Published:1998-10 Issue:10 Volume:66 Page:5031-5035
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Moxley Rodney A.¹,Berberov Emil M.¹,Francis David H.²,Xing Jun¹,Moayeri Mahtab³,Welch Rodney A.³,Baker Diane R.²,Barletta Raúl G.¹

Affiliation:

1. Departments of Veterinary and Biomedical Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska 685831;

2. Department of Veterinary Science, South Dakota State University, Brookings, South Dakota 570072; and

3. Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 537063

Abstract

ABSTRACT Pigs infected with hemolytic F4 + strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4 + enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene ( hlyA ) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.10.5031-5035.1998

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