YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging Tunicates-Reference-Cited by-同舟云学术

YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging Tunicates

Published:2021-06-23 Issue:7 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Kawamura Kaz¹^ORCID,Higuchi Takuma²,Fujiwara Shigeki¹³

Affiliation:

1. Laboratory of Cellular and Molecular Biotechnology, Faculty of Science, Kochi University, Kochi, Japan

2. Laboratory of Molecular Biology, Science Research Center, Kochi University, Kochi, Japan

3. Department of Chemistry and Life Science, Faculty of Science and Technology, Kochi University, Kochi, Japan

Abstract

In budding tunicates, aging accompanies a decrease in the gene expression of mitochondrial transcription factor A ( Tfam ), and the in vivo transfection of Tfam mRNA stimulates the mitochondrial respiratory activity of aged animals. The gene expression of both the transcriptional repressor Yin-Yang-1 ( YY1 ) and corepressor Sirtuin6 ( Sirt6 ) increased during aging, and the cotransfection of synthetic mRNA of YY1 and Sirt6 synergistically downregulated Tfam gene expression.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00047-21

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