Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release-Reference-Cited by-同舟云学术

Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release

Published:2002-02-15 Issue:4 Volume:76 Page:1578-1587
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Moise Alexander R.¹²,Grant Jason R.¹²,Vitalis Timothy Z.³,Jefferies Wilfred A.¹²

Affiliation:

1. Biotechnology Laboratory,

2. Biomedical Research Centre, and Departments of Medical Genetics, Microbiology and Immunology, and Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z3,

3. Pulmonary Research Laboratory, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia V6Z 1Y6, Canada

Abstract

ABSTRACT E3-6.7K is a small and hydrophobic membrane glycoprotein encoded by the E3 region of subgroup C adenovirus. Recently, E3-6.7K has been shown to be required for the downregulation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors by the adenovirus E3/10.4K and E3/14.5K complex of proteins. We demonstrate here that E3-6.7K has additional protective roles, independent of other virus proteins. In transfected Jurkat T-cell lymphoma cells, E3-6.7K was found to maintain endoplasmic reticulum-Ca 2+ homeostasis and inhibit the induction of apoptosis by thapsigargin. The presence of E3-6.7K also lead to a reduction in the TNF-induced release of arachidonic acid from transfected U937 human histiocytic lymphoma cells. In addition, E3-6.7K protected cells against apoptosis induced through Fas, TNF receptor, and TRAIL receptors. Therefore, E3-6.7K confers a wide range of protective effects against both Ca 2+ flux-induced and death receptor-mediated apoptosis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.4.1578-1587.2002

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