Interferon Induction in Mice by Lipopolysaccharide from Brucella abortus

Author:

Keleti Georg1,Feingold David S.1,Youngner Julius S.1

Affiliation:

1. Department of Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Abstract

Endotoxin or lipopolysaccharide isolated from Brucella abortus (strain 456) produced a typical endotoxin-type interferon response in mice with peak levels of the inhibitor occurring 2 h after intravenous injection of the stimuli. Brucella lipopolysaccharide was a much less effective interferon stimulus than the lipopolysaccharide isolated from Salmonella typhimurium (strain LT-2).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference13 articles.

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2. Interferon induction and resistance to virus infection in mice infected with Brucella abortus;Billiau A.;Infect. Immunity,1970

3. Bousquet C. M. Ramuz J. Serre and J. Roux. 197:3. Caracterisation de l'interferon produit chez la souris infectee par Brucella melitensis. Ann. Microbiol. (Inst. Pasteur). 124A:71-82.

4. The interferon inducer from;De Somer P..;Brucella. Ann. N. Y. Acad. Sci.,1970

5. Protein measurement with the Folin phenol reagent;Lowr 0.;J. Biol. Chem.,1951

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