Phagocytosis of Live Versus Heat-Killed Bacteria by Human Polymorphonuclear Leukocytes-Reference-Cited by-同舟云学术

Phagocytosis of Live Versus Heat-Killed Bacteria by Human Polymorphonuclear Leukocytes

Published:1974-07 Issue:1 Volume:10 Page:25-29
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

DeChatelet Lawrence R.¹,Mullikin Debra¹,Shirley Pamela S.¹,McCall Charles E.¹

Affiliation:

1. Departments of Biochemistry and Medicine, The Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103

Abstract

Heat-killed Pseudomonas aeruginosa are phagocytized much more slowly by human polymorphonuclear leukocytes than are the live organisms. The post-phagocytic increase in hexose monophosphate shunt activity (HMS) parallels the ingestion of the bacteria. The addition of serum to the live organisms causes a marked increase in both ingestion and cellular HMS activity; serum actually causes an inhibition of both uptake and HMS activity when added to the heat-killed organisms. Differences in postphagocytic HMS activity between live and heat-killed organisms were observed with three different species of bacteria, indicating that the phenomenon is not restricted to P. aeruginosa. These data emphasize that the influence of the particle on the phagocytic process is considerable.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.10.1.25-29.1974

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