Penetration of ceftazidime into the cerebrospinal fluid of patients with and without evidence of meningeal inflammation

Author:

Fong I W,Tomkins K B

Abstract

The concentrations of ceftazidime in the serum and cerebrospinal fluid of patients with and without meningitis were measured at various times after a 2- or 3-g dose. At similar concentrations in serum, ceftazidime concentrations in cerebrospinal fluid at a given time were substantially lower in patients without meningitis (mean, 0.8 micrograms/ml) than in those with meningitis (mean, 22.6 micrograms/ml).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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