Comparison of Bacteroides vulgatus strains in the enhancement of experimental ulcerative colitis

Author:

Onderdonk A B,Bronson R,Cisneros R

Abstract

Strains of Bacteroides vulgatus from a variety of sources were tested for their abilities to enhance the inflammatory response in an experimental model for ulcerative colitis. Although there were considerable differences noted in inflammatory responses when guinea pigs were immunized with the various strains, there did not appear to be any correlation between the source of the isolates and the severity of the carrageenan-induced lesions. Strains from patients with ulcerative colitis were no more active in the model system than were strains from patients with antibiotic-associated colitis or strains from a healthy human source. The antibody titer to the strain used for immunization did not correlate with the severity of the cecal ulcerations, as determined by histopathologic evaluation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference9 articles.

1. Colton T. 1974. Statistics in medicine 1st ed. Little Brown & Co. Boston.

2. Studies on carrageenan and large bowel ulceration in mammals;Grosso P.;Food Cosmet. Toxicol.,1973

3. Ulcerative disease of the colon in laboratory animals induced by pepsin inhibitors;Marcus R.;Gastroenterology,1974

4. Enhancement of experimental ulcerative colitis by immunization with Bacteroides vulgatus;Onderdonk A. B.;Infect. Immun.,1983

5. Production of experimental ulcerative colitis in gnotobiotic guinea pigs with simplified microflora;Onderdonk A. B.;Infect. Immun.,1981

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3