Caspofungin Disk Diffusion Breakpoints and Quality Control-Reference-Cited by-同舟云学术

Caspofungin Disk Diffusion Breakpoints and Quality Control

Published:2008-06 Issue:6 Volume:46 Page:1927-1929
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Brown Steven D.¹,Traczewski Maria M.¹

Affiliation:

1. The Clinical Microbiology Institute, 9725 SW Commerce Circle, Wilsonville, Oregon 97070

Abstract

ABSTRACT Interpretive disk diffusion breakpoints for caspofungin are proposed by evaluating 762 isolates of Candida spp., representing 10 different species obtained as part of the caspofungin clinical trials. Standardized broth microdilution reference tests were compared to the zone diameters observed with 5-μg caspofungin disks produced by two different disk manufacturers. Disk diffusion breakpoints of ≥11 mm for susceptible are proposed. Compared to results from MIC testing, these zone diameters produced error rates that were ≤0.3% for all categories. In addition, an eight-laboratory disk diffusion quality control (QC) study was performed, and QC ranges are proposed for the four QC strains recommended by the CLSI.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00279-08

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