Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-Resistant Klebsiella pneumoniae Bacteremia and Abscess in a Liver Transplant Recipient-Reference-Cited by-同舟云学术

Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-Resistant Klebsiella pneumoniae Bacteremia and Abscess in a Liver Transplant Recipient

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Athans Vasilios¹,Neuner Elizabeth A.¹,Hassouna Habiba²,Richter Sandra S.³,Keller George³,Castanheira Mariana⁴,Brizendine Kyle D.²,Mathers Amy J.⁵⁶

Affiliation:

1. Department of Pharmacy, Cleveland Clinic, Cleveland, Ohio, USA

2. Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, USA

3. Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA

4. JMI Laboratories, North Liberty, Iowa, USA

5. Division of Infectious Disease and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA

6. Clinical Microbiology Laboratory, Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA

Abstract

We report a case of a 24-year-old liver transplant recipient who developed hepatic artery thrombosis and graft failure, which was complicated by subphrenic abscess and persistent Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae bacteremia. Ceftazidime-avibactam treatment led to emergence of resistance, and alternative combination therapy failed due to persistent infection and toxicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01551-18

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