Optimization of Fluconazole Dosing for the Prevention and Treatment of Invasive Candidiasis Based on the Pharmacokinetics of Fluconazole in Critically Ill Patients

Author:

Boonstra J. M.1,Märtson A. G.1,Sandaradura I.23ORCID,Kosterink J. G. W.14,van der Werf T. S.56,Marriott D. J. E.78,Zijlstra J. G.9,Touw D. J.1,Alffenaar J. W. C.2310ORCID

Affiliation:

1. University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, the Netherlands

2. The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, Australia

3. Westmead Hospital, Sydney, Australia

4. University of Groningen, Department of Pharmacy, Section Pharmacotherapy and Pharmaceutical Care, Groningen, the Netherlands

5. University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Groningen, the Netherlands

6. University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases and Tuberculosis, Groningen, the Netherlands

7. St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales, Australia

8. Department of Clinical Microbiology and Infectious Diseases, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia

9. University of Groningen, University Medical Center Groningen, Department of Critical Care, Groningen, the Netherlands

10. Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia

Abstract

The efficacy of fluconazole is related to the area under the plasma concentration-time curve (AUC) over the MIC of the microorganism. Physiological changes in critically ill patients may affect the exposure of fluconazole, and therefore dosing adjustments might be needed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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