Iohexol-Measured Glomerular Filtration Rate and Urinary Biomarker Changes between Vancomycin and Vancomycin Plus Piperacillin-Tazobactam in a Translational Rat Model-Reference-Cited by-同舟云学术

Iohexol-Measured Glomerular Filtration Rate and Urinary Biomarker Changes between Vancomycin and Vancomycin Plus Piperacillin-Tazobactam in a Translational Rat Model

Published:2023-08-17 Issue:8 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chang Jack¹²³,Pais Gwendolyn M.¹²^ORCID,Marianski Sylwia¹,Valdez Kimberly¹,Lesnicki Emily⁴,Barreto Erin F.⁵^ORCID,Scheetz Marc H.¹²³⁶^ORCID

Affiliation:

1. Midwestern University-Downers Grove Campus, Department of Pharmacy Practice, Downers Grove, Illinois, USA

2. Midwestern University-Downers Grove Campus, Pharmacometrics Center of Excellence, Downers Grove, Illinois, USA

3. Northwestern Memorial Hospital, Department of Pharmacy, Chicago, Illinois, USA

4. Midwestern University-Downers Grove Campus, College of Graduate Studies, Downers Grove, Illinois, USA

5. Mayo Clinic, Department of Pharmacy, Rochester, Minnesota, USA

6. Midwestern University-Downers Grove Campus, Department of Pharmacology, Downers Grove, Illinois, USA

Abstract

Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam. However, preclinical models have failed to replicate this finding.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00304-23

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