A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women-Reference-Cited by-同舟云学术

A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Moore Brioni R.¹²,Benjamin John M.³,Tobe Roselyn³,Ome-Kaius Maria³⁴⁵,Yadi Gumul³,Kasian Bernadine³,Kong Charles³,Robinson Leanne J.³⁴⁵⁶,Laman Moses²³,Mueller Ivo⁴⁵⁷,Rogerson Stephen⁸,Davis Timothy M. E.²^ORCID

Affiliation:

1. School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia

2. Medical School, The University of Western Australia, Crawley, Australia

3. Vector Borne Disease Unit, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

4. Population Health and Immunity Division, Walter and Eliza Hall Institute, Parkville, Australia

5. Department of Medical Biology, University of Melbourne, Parkville, Australia

6. Burnet Institute, Melbourne, Australia

7. Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France

8. Department of Medicine, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia

Abstract

Emerging malaria parasite sulfadoxine-pyrimethamine (SP) resistance has prompted assessment of alternatives for intermittent preventive treatment in pregnancy (IPTp). The objective was to evaluate the tolerability and prophylactic efficacy of azithromycin (AZ) plus piperaquine (PQ) in pregnant women in Papua New Guinea. The study was an open-label, randomized, parallel-group trial.

Funder

Malaria in Pregnancy Consortium

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00302-19

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4. World Health Organization. 2015. Guidelines for the treatment of malaria. World Health Organization, Geneva, Switzerland.

5. Effect of Sulfadoxine-Pyrimethamine Resistance on the Efficacy of Intermittent Preventive Therapy for Malaria Control During Pregnancy

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