Two Novel Antibiotic Resistance Genes, tet (44) and ant(6)-Ib , Are Located within a Transferable Pathogenicity Island in Campylobacter fetus subsp. fetus-Reference-Cited by-同舟云学术

Two Novel Antibiotic Resistance Genes, tet (44) and ant(6)-Ib , Are Located within a Transferable Pathogenicity Island in Campylobacter fetus subsp. fetus

Published:2010-07 Issue:7 Volume:54 Page:3052-3055
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abril Carlos¹,Brodard Isabelle¹,Perreten Vincent²

Affiliation:

1. Centre for Zoonoses, Bacterial Animal Diseases and Antimicrobial Resistance (ZOBA)

2. Molecular Bacterial Epidemiology and Infectiology, Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Berne, Switzerland

Abstract

ABSTRACT New tetracycline and streptomycin resistance genes, tet (44) and ant(6)-Ib , were identified in Campylobacter fetus subsp. fetus within a transferable pathogenicity island that is typically unique to Campylobacter fetus subsp. venerealis . The 640-amino-acid tetracycline resistance determinant, Tet 44, belongs to a class of proteins that confers resistance to tetracycline and minocycline by ribosomal protection. The 286-amino-acid streptomycin resistance determinant, ANT(6)-Ib, belongs to a family of aminoglycoside nucleotidyltransferases. The resistance phenotypes were demonstrated by gene inactivation and expression.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00304-10

Reference22 articles.

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