Cefepime Population Pharmacokinetics, Antibacterial Target Attainment, and Estimated Probability of Neurotoxicity in Critically Ill Patients-Reference-Cited by-同舟云学术

Cefepime Population Pharmacokinetics, Antibacterial Target Attainment, and Estimated Probability of Neurotoxicity in Critically Ill Patients

Published:2023-07-18 Issue:7 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bilal Muhammad¹²^ORCID,Zoller Michael³,Fuhr Uwe¹,Jaehde Ulrich²,Ullah Sami¹,Liebchen Uwe³^ORCID,Büsker Sören¹,Zander Johannes⁴,Babouee Flury Baharak⁵^ORCID,Taubert Max¹

Affiliation:

1. University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, Cologne, Germany

2. Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, Bonn, Germany

3. Department of Anaesthesiology, Hospital of the Ludwig Maximilians University of Munich, Munich, Germany

4. Laboratory of Dr. Brunner, Constance, Germany

5. Division of Infectious Diseases and Hospital Epidemiology, Kantonsspital St. Gallen, St. Gallen, Switzerland

Abstract

Cefepime has been reported to cause concentration-related neurotoxicity, especially in critically ill patients with renal failure. This evaluation aimed to identify a dosing regimen providing a sufficient probability of target attainment (PTA) and the lowest justifiable risk of neurotoxicity in critically ill patients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00309-23

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