Role of Synonymous Mutations in the Evolution of TEM β-Lactamase Genes-Reference-Cited by-同舟云学术

Role of Synonymous Mutations in the Evolution of TEM β-Lactamase Genes

Published:2021-05-18 Issue:6 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Faheem Mohammad¹,Zhang Charles J.¹^ORCID,Morris Monica N.¹^ORCID,Pleiss Juergen²^ORCID,Oelschlaeger Peter¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA

2. Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Stuttgart, Germany

Abstract

Nonsynonymous mutations are well documented in TEM β-lactamases. The resulting amino acid changes often alter the conferred phenotype from the broad spectrum (2b) conferred by TEM-1 to extended spectrum (2be), inhibitor resistant (2br), or both extended spectrum and inhibitor resistant (2ber).

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00018-21

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