Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy-Reference-Cited by-同舟云学术

Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy

Published:2022-07-19 Issue:7 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Michaels Samantha A.¹,Hulverson Matthew A.¹,Whitman Grant R.¹,Tran Linh T.¹,Choi Ryan¹,Fan Erkang²,McNamara Case W.³,Love Melissa S.³,Ojo Kayode K.¹^ORCID

Affiliation:

1. Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA

2. Department of Biochemistry, University of Washington, Seattle, Washington, USA

3. Calibr, Division of the Scripps Research Institute, La Jolla, California, USA

Abstract

A phenotypic screen of the ReFRAME compound library was performed to identify cell-active inhibitors that could be developed as therapeutics for giardiasis. A primary screen against Giardia lamblia GS clone H7 identified 85 cell-active compounds at a hit rate of 0.72%.

Funder

Bill and Melinda Gates Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00017-22

Reference53 articles.

1. High Prevalence of Giardia duodenalis Assemblage B Infection and Association with Underweight in Rwandan Children

2. Treatment-refractory giardiasis: challenges and solutions

3. Increased incidence of nitroimidazole-refractory giardiasis at the Hospital for Tropical Diseases, London: 2008–2013

4. Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2)

5. Drug Resistance in the Microaerophilic Parasite Giardia lamblia

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Perspectives on the drug discovery of intestinal protozoan parasites;Intestinal Parasites - New Developments in Diagnosis, Treatment, Prevention and Future Directions [Working Title];2024-06-04

2. The Gut-Wrenching Effects of Cryptosporidiosis and Giardiasis in Children;Microorganisms;2023-09-15

3. Identification of Fungus-Derived Natural Products as New Antigiardial Scaffolds;Microbiology Spectrum;2023-06-15

4. Ultrastructural Alterations of the Human Pathogen Giardia intestinalis after Drug Treatment;Pathogens;2023-06-07