MarA-Like Regulator of Multidrug Resistance in Yersinia pestis-Reference-Cited by-同舟云学术

MarA-Like Regulator of Multidrug Resistance in Yersinia pestis

Published:2006-09 Issue:9 Volume:50 Page:2971-2975
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Udani Rupa A.¹,Levy Stuart B.¹²

Affiliation:

1. Center of Adaptation Genetics and Drug Resistance and Department of Molecular Biology and Microbiology

2. Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111

Abstract

ABSTRACT MarA47 Yp from Yersinia pestis , showing 47% identity to Escherichia coli MarA in its N terminus, caused resistance to antibiotics and to organic solvents when expressed in both E. coli and Y. pestis . Resistance was linked to increased expression of the AcrAB multidrug efflux pump. In four of five spontaneous multidrug-resistant mutants of Y. pestis independently selected by growth on tetracycline, the marA47 Yp gene was overexpressed. The findings suggest that marA47 Yp is a marA ortholog in Y. pestis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00015-06

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