Biological and Biochemical Evaluation of Isatin-Isoniazid Hybrids as Bactericidal Candidates against Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Biological and Biochemical Evaluation of Isatin-Isoniazid Hybrids as Bactericidal Candidates against Mycobacterium tuberculosis

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Johansen Matt D.¹²^ORCID,Shalini ³,Kumar Sumit³,Raynaud Clément¹,Quan Diana H.⁴,Britton Warwick J.⁵⁶,Hansbro Philip M.²,Kumar Vipan³,Kremer Laurent¹⁷^ORCID

Affiliation:

1. Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France

2. Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia

3. Department of Chemistry, Guru Nanak Dev University, Punjab, India

4. Tuberculosis Research Program, Centenary Institute, The University of Sydney, Camperdown, NSW, Australia

5. Centenary Institute, The University of Sydney, Camperdown, NSW, Australia

6. Department of Clinical Immunology, Royal Prince Alfred Hospital, Sydney, NSW, Australia

7. INSERM, IRIM, Montpellier, France

Abstract

Tuberculosis remains a leading cause of mortality among infectious diseases worldwide, prompting the need to discover new drugs to fight this disease. We report here the design, synthesis, and antimycobacterial activity of isatin-mono/bis-isoniazid hybrids.

Funder

Department of Science and Technology, India

Council of Scientific and Industrial Research, India

National Health and Medical Research Council

NHMRC Centre of Research Excellence in TB Control

Association Vaincre la Mucoviscidose

Department of Health, Australian Government | National Health and Medical Research Council

French National Research Agency

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00011-21

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