Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus-Reference-Cited by-同舟云学术

Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus

Published:2019-05 Issue:5 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fujii Hikaru¹²,Harada Shizuko¹,Yoshikawa Tomoki¹,Yamada Souichi¹,Omura Natsumi¹³,Shibamura Miho¹⁴,Inagaki Takuya¹³,Kato Hirofumi¹,Fukushi Shuetsu¹,Saijo Masayuki¹³

Affiliation:

1. Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

2. The Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Ehime, Japan

3. Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan

4. Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Abstract

Acyclovir (ACV) resistance-associated mutations in two recombinant herpes simplex virus 1 (HSV-1) clones were compared. Recombinant HSV-1 lacking its thymidine kinase (TK) and expressing varicella-zoster virus (VZV) TK ectopically had no mutations in the VZV TK gene.

Funder

Ministry of Health, Labour and Welfare

Ministry of Education, Culture, Sports, Science and Technology

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00017-19

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