Affiliation:
1. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH), Instituto Oswaldo Cruz—FIOCRUZ, Rio de Janeiro, Brazil
Abstract
ABSTRACT
We aimed to investigate polymyxin B (PMB) resistance and its molecular mechanisms in 126
Klebsiella pneumoniae
isolates from rectal swabs in Brazil. Ten isolates exhibited PMB resistance with interruption of
mgrB
gene by insertion sequences or missense mutations. Most of the PMB-resistant isolates harbored
bla
KPC-2
(
n
= 8) and belonged to clonal complex 258 (CC258) (
n
= 7). These results highlight the importance of monitoring the spread of polymyxin-resistant bacteria in hospitals, since few options remain to treat multidrug-resistant isolates.
Funder
MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico
PAPES/Oswaldo Cruz Institute
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
59 articles.
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