Pyrrolomycins Are Potent Natural Protonophores-Reference-Cited by-同舟云学术

Pyrrolomycins Are Potent Natural Protonophores

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Valderrama Katherine¹,Pradel Elizabeth¹²,Firsov Alexander M.³,Drobecq Hervé¹,Bauderlique-le Roy Hélène⁴,Villemagne Baptiste⁵,Antonenko Yuri N.³,Hartkoorn Ruben Christiaan¹^ORCID

Affiliation:

1. Centre for Infection and Immunity of Lille, U1019-UMR8204, Université Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France

2. Inserm U995–LIRIC-Lille Inflammation Research International Center, Université Lille, CHU Lille, Lille, France

3. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia

4. Flow Core Facility, BioImaging Center of Lille, Institut Pasteur de Lille, Lille, France

5. Drugs and Molecules for Living Systems, Université Lille, Inserm U1177, Institut Pasteur de Lille, Lille, France

Abstract

The escalating burden of antibiotic drug resistance necessitates research into novel classes of antibiotics and their mechanism of action. Pyrrolomycins are a family of potent natural product antibiotics with nanomolar activity against Gram-positive bacteria, yet with an elusive mechanism of action.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01450-19

Reference35 articles.

1. Natural Products as Sources of New Drugs from 1981 to 2014

2. Pyrrolomycins C,D and E,new members of pyrrolomycins.

3. Cloning and Characterization of the Pyrrolomycin Biosynthetic Gene Clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. Strain UC 11065

4. Additional Pyrrolomycins from Cultures of Streptomyces fumanus

5. Pyrrolomycins as potential anti-staphylococcal biofilms agents

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