A Model for Transposition of the Colistin Resistance Gene mcr-1 by IS Apl1-Reference-Cited by-同舟云学术

A Model for Transposition of the Colistin Resistance Gene mcr-1 by IS Apl1

Published:2016-11 Issue:11 Volume:60 Page:6973-6976
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Snesrud Erik¹,He Susu²,Chandler Michael³,Dekker John P.⁴,Hickman Alison B.²,McGann Patrick¹,Dyda Fred²

Affiliation:

1. Multidrug-resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

2. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

3. Laboratoire de Microbiologie et Genetique Moleculaires, Centre National de la Recherche Scientifique, Toulouse, France

4. Department of Laboratory Medicine, Clinical Center, Microbiology Service, National Institutes of Health, Bethesda, Maryland, USA

Abstract

ABSTRACT Analysis of mcr-1 -containing sequences identified a common ∼2,607-bp DNA segment that in many cases is flanked on one or both ends by IS Apl1 . We present evidence that mcr-1 is mobilized by an IS Apl1 composite transposon which has, in some cases, subsequently lost one or both copies of IS Apl1 . We also show that mcr-1 can be mobilized in some circumstances by a single upstream copy of IS Apl1 in conjunction with the remnants of a downstream IS Apl1 .

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01457-16

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