Genomic Stability of Legionella pneumophila Isolates Recovered from Two Cardiac Transplant Patients with Nosocomial Legionnaires' Disease

Author:

Marrie Thomas J.12,Johnson Wendy M.23,Tyler Shaun D.3,Bezanson Gregory S.2,Burbridge Susan1

Affiliation:

1. Department of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada

2. Department of Microbiology, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada

3. Laboratory Centre for Disease Control, Ottawa, Ontario, Canada

Abstract

Pulsed-field gel electrophoresis revealed that multiple consecutive isolates of Legionella pneumophila from two cardiac transplant patients remained genomically stable, despite exposure to host defenses and antimicrobial agents.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference16 articles.

1. Bezanson G. S. J. Joly S. M. Burbridge R D. Kuehn D. J. M. Haldane and T. J. Marrie. 1993. Phenotypic and genotypic variability of Legionella pneumophila populating potable waters and patients of a tertiary-care hospital over a five-year period p. 275-278. In J. M. Barbaree R. F. Breiman and A. P. Dufour (ed.) Legionella: current status and emerging perspectives. American Society for Microbiology Washington D.C.

2. Determination of the activity on Legionella of eight macrolides and related agents by comparative testing on three media;Bornstein N.;Antimicrob. Chemother.,1985

3. Legionnaires' disease following cardiac transplantation;Copeland J.;Chest,1981

4. Dillon J. R. G. S. Bezanson and K. H. Young. 1985. Basic techniques p. 1-126. In J. R. Dillon A. Nasism and E. Nestman (ed.) Recombinant DNA methodology. John Wiley & Sons Inc. Toronto.

5. Pneumonia and multiple Iung abscesses caused by dual infection with Legionella micdadei and Legionella pneumophila;Dowling J. N.;Am. Rev. Respir. Dis.,1983

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