Induction of Inflammatory Responses in Splenocytes by Exosomes Released from Intestinal Epithelial Cells following Cryptosporidium parvum Infection-Reference-Cited by-同舟云学术

Induction of Inflammatory Responses in Splenocytes by Exosomes Released from Intestinal Epithelial Cells following Cryptosporidium parvum Infection

Published:2019-04 Issue:4 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Wang Yang¹,Shen Yujuan²,Liu Hua²,Yin Jianhai²,Zhang Xin-Tian¹,Gong Ai-Yu¹,Chen Xiqiang¹,Chen Siyi³,Mathy Nicholas W.¹,Cao Jianping²,Chen Xian-Ming¹

Affiliation:

1. Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA

2. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China

3. Creighton University School of Pharmacy and Health Professions, Omaha, Nebraska, USA

Abstract

Cryptosporidium , a protozoan parasite that infects the gastrointestinal epithelium and other mucosal surfaces in humans and animals, is an important opportunistic pathogen in AIDS patients and one of the most common enteric pathogens affecting young children in developing regions. This parasite is referred to as a “minimally invasive” mucosal pathogen, and epithelial cells play a central role in activating and orchestrating host immune responses.

Funder

HHS | National Institutes of Health

Creighton University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00705-18

Reference49 articles.

1. Parasitic infections: Time to tackle cryptosporidiosis

2. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium