Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation
Author:
Affiliation:
1. Departments of Neurology and Cellular and Molecular Pharmacology, UCSF, San Francisco, California 94143
2. Department of Surgery, UCSF, San Francisco, California 94143
3. Neurogenetics Branch, NIH, Bethesda, Maryland 20892
Abstract
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Link
https://journals.asm.org/doi/pdf/10.1128/MCB.00079-08
Reference54 articles.
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3. Bamburg, J. R. 1999. Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu. Rev. Cell Dev. Biol.15:185-230.
4. Bjorkegren, C., M. Rozycki, C. E. Schutt, U. Lindberg, and R. Karlsson. 1993. Mutagenesis of human profilin locates its poly(L-proline)-binding site to a hydrophobic patch of aromatic amino acids. FEBS Lett.333:123-126.
5. Burnett, B. G., J. Andrews, S. Ranganathan, K. H. Fischbeck, and N. A. Di Prospero. 2008. Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics. Neurobiol. Dis.30:365-374.
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