Affiliation:
1. Research Institute of Tuberculosis, Toneyama Hospital, National Sanatorium, Toyonaka, Osaka, Japan 560
Abstract
Sera of man and animals infected with tubercle bacilli were tested for precipitating antibody to trehalose-6, 6′-dimycolate (cord factor) of
Mycobacterium tuberculosis
. None of the sera of mice and rabbits infected with
M. tuberculosis
H37Rv reacted with cord factor, whereas the sera of animals vaccinated with cord factor-methylated bovine serum albumin complex demonstrated a precipitin reaction with cord factor. Antibody against cord factor was not detected in the sera of cases of active, convalescent, and pneumonectomized human tuberculosis, indicating that the anti-cord factor antibody is not associated with tuberculous infection in man and animals. Precipitin activity against cord factor was localized in 19
S
macroglobulin (immunoglobulin M) fraction of the serum of rabbits vaccinated with cord factor-methylated bovine serum albumin complex. Analytical gel filtration and immunodiffusion studies indicated that the anti-cord factor precipitin dissociated from the cord factor-antibody complex is an immunoglobulin M antibody.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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