The Set1 Histone H3K4 Methyltransferase Contributes to Azole Susceptibility in a Species-Specific Manner by Differentially Altering the Expression of Drug Efflux Pumps and the Ergosterol Gene Pathway-Reference-Cited by-同舟云学术

The Set1 Histone H3K4 Methyltransferase Contributes to Azole Susceptibility in a Species-Specific Manner by Differentially Altering the Expression of Drug Efflux Pumps and the Ergosterol Gene Pathway

Published:2022-05-17 Issue:5 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Baker Kortany M.¹,Hoda Smriti¹,Saha Debasmita¹,Gregor Justin B.¹,Georgescu Livia¹,Serratore Nina D.¹,Zhang Yueping¹,Cheng Lizhi¹,Lanman Nadia A.²³,Briggs Scott D.¹²^ORCID

Affiliation:

1. Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA

2. Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA

3. Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA

Abstract

Fungal infections are a major health concern because of limited antifungal drugs and development of drug resistance. Candida can develop azole drug resistance by overexpression of drug efflux pumps or mutating ERG11 , the target of azoles. However, the role of epigenetic histone modifications in azole-induced gene expression and drug resistance is poorly understood in Candida glabrata .

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

USDA | National Institute of Food and Agriculture

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02250-21

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