Optimal Detection of Latent Mycobacterium tuberculosis Infection by Combined Heparin-Binding Hemagglutinin (HBHA) and Early Secreted Antigenic Target 6 (ESAT-6) Whole-Blood Interferon Gamma Release Assays-Reference-Cited by-同舟云学术

Optimal Detection of Latent Mycobacterium tuberculosis Infection by Combined Heparin-Binding Hemagglutinin (HBHA) and Early Secreted Antigenic Target 6 (ESAT-6) Whole-Blood Interferon Gamma Release Assays

Published:2022-05-18 Issue:5 Volume:60 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Dirix V.¹,Dauby N.²³,Hites M.⁴,Watelet E.⁵,Van Praet A.¹,Godefroid A.¹,Petit E.⁶,Singh M.⁷,Locht C.⁶,Mascart F.¹^ORCID,Corbière V.¹

Affiliation:

1. Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles, Brussels, Belgium

2. Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium

3. Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium

4. Department of Infectious and Tropical Diseases, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium

5. Department of Pneumology, Clinique St. Anne/St. Remi-CHIREC, Brussels, Belgium

6. Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U-1019, UMR8204, Center for Infection and Immunity of Lille, Lille, France

7. Lionex Diagnostics and Therapeutics, Braunschweig, Germany

Abstract

Optimal detection of latent tuberculosis (TB) infection (LTBI) remains a challenge, although it is essential to reach the goal of TB elimination. Our objective was to develop and clinically evaluate a user-friendly, 24-h, whole-blood (WB) interferon gamma (IFN-γ) release assay (IGRA) improving the detection of LTBI, compared to available tests.

Funder

Tuberculosis Vaccine Initiative

INNOV-IRIS Brussels

European Commission

Fonds De La Recherche Scientifique - FNRS

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.02443-21

Reference32 articles.

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2. LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement

3. Latent tuberculosis infection: the final frontier of tuberculosis elimination in the USA

4. Fourth-Generation QuantiFERON-TB Gold Plus: What Is the Evidence?

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