Human polymorphonuclear leukocyte response to Pseudomonas aeruginosa grown in biofilms

Author:

Jensen E T1,Kharazmi A1,Lam K1,Costerton J W1,Høiby N1

Affiliation:

1. Department of Clinical Microbiology, Statens Seruminstitut, Copenhagen, Denmark.

Abstract

The interaction of human neutrophils with Pseudomonas aeruginosa biofilms was examined by using a chemiluminescence assay. The biofilms induced an oxidative burst response by polymorphonuclear leukocytes which was slow and only 25% of the response to planktonic bacteria. The reduced response to P. aeruginosa biofilms could play a role in the persistence of bacteria in chronic infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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