Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England-Reference-Cited by-同舟云学术

Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England

Published:1998-04 Issue:4 Volume:42 Page:868-872
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Christophers Jacqueline¹,Clayton Julie¹,Craske John¹,Ward Rosemary¹,Collins Peter²,Trowbridge Martin²,Darby Graham²

Affiliation:

1. Manchester Public Health Laboratory, Withington Hospital, Manchester, M20 2LR,1and

2. GlaxoWellcome Research Laboratories, Stevenage, SG1 2NY,2 United Kingdom

Abstract

ABSTRACT Acyclovir (ACV) has been used for more than 15 years in the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) disease. The present survey was undertaken to assess the level of ACV resistance in the population. More than 2,000 HSV isolates from both immunocompetent and immunocompromised patients in northwest England were collected over a 2-year period and tested for sensitivity to ACV. These studies suggested a prevalence of resistance of approximately 0.1 to 0.6% in immunocompetent individuals, with no apparent difference in prevalence between treated and untreated groups. In line with previous studies, the prevalence of resistance in treated immunocompromised individuals was approximately 6%.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.4.868

Reference21 articles.

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4. Characterisation of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir.;Collins P.;J. Gen. Virol.,1989

5. Collins P. and N. M. Oliver. 1986. Sensitivity monitoring of herpes simplex virus isolates from patients receiving acyclovir. J. Antimicrob. Chemother. 18 (Suppl. B) : 103–112.

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