Synthesis and Antibacterial Evaluation of Novel Water-Soluble Organic Peroxides-Reference-Cited by-同舟云学术

Synthesis and Antibacterial Evaluation of Novel Water-Soluble Organic Peroxides

Published:1998-04 Issue:4 Volume:42 Page:911-915
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Liu Wenqiu¹,Liu Xuejun¹,Knaebel David²,Luck Linda²,Li Yuzhou¹

Affiliation:

1. Department of Chemistry,1 and

2. Department of Biology,2 Clarkson University, Potsdam, New York 13699

Abstract

ABSTRACT A set of new water-soluble organic peroxides has been synthesized and evaluated for in vitro antibacterial activity as part of an effort to develop new antibacterial agents for the treatment of acne vulgaris. The water solubility of these new dialkyl peroxides and peroxyesters was achieved by incorporating either a quaternary ammonium group or a polyethylene glycol moiety. These peroxides are effective against both gram-positive and gram-negative bacteria and have a prolonged activity compared to that of benzoyl peroxide and other peroxide-type antiseptic agents. Among them 4-[[( tert -butylperoxy)carbonyl]benzyl]triethylammonium chloride and [10-( tert -butylperoxy)decyl]trimethylammonium bromide have the broadest antimicrobial spectrums. We have shown that the oxidizing properties of the dioxy group of these compounds are responsible for their antibacterial activities.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.4.911

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