Decrease in antimicrobial susceptibility of Bordetella bronchiseptica caused by antigenic modulation and phase variation

Author:

Ishikawa H1,Isayama Y1,Ohmae K1

Affiliation:

1. Hokkaido Research Station, National Institute of Animal Health, Sapporo, Japan.

Abstract

The susceptibilities to 20 antimicrobial agents of Bordetella bronchiseptica variants in C mode and degraded phases were compared with those of their parents in X mode. Increases in MICs of 4- to 32-fold were observed for ampicillin, carbenicillin, erythromycin, novobiocin, rifampin, chloramphenicol, nalidixic acid, and oxolinic acid.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

1. Antibiotic resistance of degraded strains of Bordetella pertussis;Bannatyne R. M.;Antimicrob. Agents Chemother.,1984

2. The antibiotic sensitivity of Bordetella in South Australia;Cooper R. G.;Med. J. Aust.,1967

3. Phase-shift markers in Bordetella: alterations in envelope proteins;Ezzeli J. W.;J. Infect. Dis.,1981

4. Bordetella bronchiseptica phase variation induced by crystal violet;Ishikawa H.;J. Clin. Microbiol.,1986

5. Effect of antigenic modulation and phase variation on adherence of Bordetella bronchiseptica to porcine nasal epithelial cells;Ishikawa H.;Am. J. Vet. Res.,1987

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