Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry-Reference-Cited by-同舟云学术

Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry

Published:2001-03-15 Issue:6 Volume:75 Page:3038-3042
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hildinger Markus¹,Dittmar Matthias T.¹,Schult-Dietrich Patricia²,Fehse Boris³,Schnierle Barbara S.²,Thaler Sonja²,Stiegler Gabriela⁴,Welker Reinhold¹,von Laer Dorothee¹

Affiliation:

1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg,1

2. Georg-Speyer-Haus, 60596 Frankfurt,2Germany, and

3. Zentrum für Knochenmarktransplantation, Universitätskrankenhaus Eppendorf,3 D-20251 Hamburg, and

4. Institute of Applied Microbiology, A-1190 Vienna, Austria4

Abstract

ABSTRACT Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.6.3038-3042.2001

Reference30 articles.

1. Generation of human monoclonal antibodies against HIV-1 proteins; electrofusion and Epstein-Barr virus transformation for peripheral blood lymphocyte immortalization;Buchacher A.;AIDS Res. Hum. Retrovir.,1994

2. Core structure of gp41 from the HIV envelope glycoprotein;Chan D. C.;Cell,1997

3. Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy;Chun T.-W.;Nat. Med.,1999

4. High-titer packaging cells producing recombinant retroviruses resistant to human serum

5. Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket;Eckert D. M.;Cell,1999

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